Colorectal cancers arise from earlier growths, called polyps, found on the inner surface of the colon. Scientists are now learning that polyps use two distinct molecular pathways as they progress to cancer, called the "conventional" and "alternative" pathways. The latter leads to an often treatment-resistant tumor, called serrated colorectal cancer; thus, distinguishing between these two cancer types holds implications for patient care. However, lack of a diagnostic test to identify serrated colorectal cancer has limited doctors' and scientists' understanding of this cancer type-and has hindered the development of effective treatments.
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