A study using a PET scan tracer developed at the Martinos Center for Biomedical Imaging at Massachusetts General Hospital (MGH) has identified, for the first time, epigenetic differences between the brains of individuals with schizophrenia and those of unaffected study participants. In their report published online in the Journal of Clinical Investigation, the MGH team describes measuring differences in the expression of histone deacetylase (HDAC) enzymes, important regulators of gene transcription, in a brain structure known to be important for key cognitive functions. While reduced HDAC levels had previously been observed in postmortem brain samples from patients with schizophrenia, use of the tracer, named Martinostat, allows measurement of HDACs in the brains of living individuals.
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